Vaporized Hydrogen Peroxide – Applications and Monitoring Solutions

Sterilizing medical instruments in autoclave

Vaporized Hydrogen Peroxide is one of the few sterilization methods that is effective for virus deactivation and microbial reduction. This blog post discusses various aspects of the sterilization market and the need for spectroscopic monitoring equipment for validating hardware and sterilization cycle design.

Reducing Nosocomial or Hospital-Acquired Infections, Miniaturizing Technology for Table-Top Office Sterilizers

The future of the sterilization market is in small semiportable sterilization isolators geared towards doctors’ offices and other front-line medical personnel. The driving force behind the adoption of this technology is the reduction of nosocomial or hospital-acquired infections. Medical equipment is routinely disinfected with alcohol between each patient, but that is not always enough to properly disinfect the instruments. By placing medical equipment, such as a stethoscope into a microwave sized chamber, medical staff can be assured that the item is properly sterilized. If a protocol is established to effectively and efficiently sterilize equipment after each patient is treated nosocomial infections will be reduced.

Using Spectroscopy to Compliment Rapid Biological Indicators

Biological indicators (BI) are the final go/no go of sterilization testing. By placing biological indicators in the sterilization chamber with the load (product to be sterilized), technicians can verify to regulatory standards that a kill dose of sterilant was received. Guided Wave’s HPV analyzer was developed to complement BI technology, by providing a real-time read-out of the sterilant concentration. If a biological indicator shows that a kill dose was not received the data produced by the Hydrogen Peroxide Vapor Analyzer can be used to help explain what went wrong with the sterilization cycle.  By combining biological indicators with spectroscopy, engineers designing the next generation of tabletop sterilizers can reduce the time to market for new products.

Benefits of Simultaneous Measurement of Water Vapor and Peroxide Vapor Concentration

A critical parameter during sterilization cycle development and validation of new sterilization hardware is that the product’s (item to be sterilized) surface is exposed for a minimum amount of time to the correct concentration of sterilant. In the case of vaporized hydrogen peroxide, one parameter to consider is the decomposition rate of hydrogen peroxide to water. By simultaneously measuring the water vapor and the hydrogen peroxide vapor, reaction kinetics can be determined.1 Spectroscopy is an accurate and reliable method to simultaneous determine water and hydrogen peroxide vapor.

The reaction kinetics (adsorption, absorption, and decomposition) of vaporized hydrogen peroxide (VHP) in a vacuum isolator will deviate from theoretical calculations as calculated by a mass balance equation.2 The Hydrogen Peroxide Vapor Analyzer uses near-infrared spectroscopy to measure the actual VHP and water vapor concentrations, corrections to reaction kinetics can be determined.  

Moreover, the water concentration is a critical measurement because it helps the engineers developing the sterilization cycle to avoid condensation. If hydrogen peroxide begins to rain inside of the sterilization chamber, the liquid may corrode or damage the products being sterilized. Condensation will also negatively impact the ability of the optics in the G-SST probe (link) to function as desired.

According to the scientific study by Corveleyn3 spectrally gaseous Water (H2O) has near-infrared absorbance peaks located at 1364 nm, 1378 nm, and 1400 nm. Whereas Hydrogen Peroxide Vapor (H2O2) was determined to have an absorbance peak located at 1420 nm. By selecting these wavelengths with the corresponding baseline corrections. The Hydrogen Peroxide Vapor Analyzer is factory calibrated to account for the interference. 

Why use Vacuum Sterilization?

Creating a vacuum is a critical part of many hydrogen peroxide sterilization systems. By pulling a vacuum inside of the sterilization chamber the air and other contaminants are removed. This prevents the air and contaminates from breaking down the hydrogen peroxide vapor prior to it reacting with the bacteria. Additionally, the vacuum may help drive the sterilant gas into the packaging material. The vacuum also increases the effectiveness of any aeration at the end of the cycle to neutralize the sterilant.

Monitoring the Vaporized Hydrogen Peroxide Concentration in Walk-in Vacuum Sterilization Isolators

Walk-in sterilization systems are used for high volume sterilization. Carts or mobile racks of the product can be loaded into and out of the isolation chamber to ensure high throughput. To ensure that proper mixing is achieved several G-SST probes can be placed in the isolation chamber. The data generated by the multiple probes provides a profile gradient that can be monitored during the sterilization process. Determining the sterilant gradient inside of a reaction chamber is an important step in validating the design of the chamber.

Bio-safety Room Decontamination and Virus Deactivation

Similar to isolators, BioSafety labs are large rooms used for biological experiments. Due to the nature of the research conducted, these rooms require periodic decontamination and virus deactivation. The National Cancer Institute (NIH) Research and Production Center at Ft. Detrick, Maryland uses vaporized hydrogen peroxide to decontaminate whole areas and rooms. The NIH facility uses spectroscopy to monitor sterilant levels in hard to access locations. Mounting a G-SST probe instead of a biological indicator in these locations saves time and increases technician safety. Learn more about this customer success story.

References

  1. https://pdfs.semanticscholar.org/9171/1c2b3ab32a797ac259598be912023a413549.pdf
  2. Brown, et al., “Calibration of Near-Infrared (NIR) H2O2 Vapor Monitor,” Pharm. Eng. 18, (6), 66–76, (1998)
  3. Corveleyn, S., Vandenbossche, G.M.R. & Remon, J.P. Near-Infrared (NIR) Monitoring of H2O2 Vapor Concentration During Vapor Hydrogen Peroxide (VHP) Sterilisation. Pharm Res14, 294–298 (1997). https://doi.org/10.1023/A:1012085702372

NASA uses HPV Analyzer to Help Keep Planets Protected

HPVA Helps Keep Plants Clean

NASA is going to Mars in 2020. The Mars 2020 Rover Mission is specifically looking for life on the Red Planet and will hunt for microscopic fossils. NASA is using Guided Wave’s Hydrogen Peroxide Vapor Analyzers (HPVAs) to help ensure that everything leaving Earth is sterilized so they don’t contaminate Mars.

The Guided Wave HPV analyzer is a simple turnkey solution for the measurement of hydrogen peroxide and water (H2O2 and H2O) concentrations in vapor phase. These are both measured together because they are codependent. The analyzer operates in real-time, which takes the guesswork out of determining the H2O2 and H2O concentrations during cycle development and throughout the actual sterilization cycle. NASA will gain continuous, accurate data for documentation and validation by using Guided Wave’s HPVA.

Why Choose Vapor Hydrogen Peroxide (VHP) Sterilization

Thermally sensitive electronics and hardware on modern spacecraft are not compatible with heat microbial reduction (HMR).  As a result, various low temperature vapor phase sterilization methods were considered. Ethylene oxide with Methyl bromide and Formaldehyde with Paraformaldehyde leave organic residue. Consequently, these alternatives are not ideal for organic sensitive hardware. On the other hand, Hydrogen peroxide (H2O2) does not leave organic residue. Oxygen and water are the only by-products. VHP is also cheaper, ideal for heat-sensitive parts, more efficient and takes less time to process than HMR.

The Jet Propulsion Laboratory (JPL) at the Biotechnology and Planetary Protection Group conducted literature review and research work to define process specifications in order to pursue vapor phase hydrogen peroxide (VHP) as an alternative sterilization technique. Quoted from their site,

“During research work, microbes were selected to test the lethality of the technique, including Bacillus stearothermophilus, Bacillus subtilis var. niger, Bacillus pumilus and Bacillus circulans.”

The microbes were deposited on different materials including aluminum, polymer, paint, and epoxied graphite. Following the research work and results, NASA PPO granted approval to use this technique for spacecraft subsystems and systems.

The initial stage for VHP sterilization involves a vacuum chamber where water is evacuated from the environment. In the next stage, H2O2 is injected into the chamber. In the third stage, sterile filtered air is injected into the chamber, which allows H2O2 vapor to penetrate the packaging and diffusion restricted areas to enhance the efficacy of the sterilization process. In the final stages of the process, the chamber is evacuated once more, followed by venting with sterile filtered air: the concentration of hydrogen peroxide vapor returns to ambient levels and the enclosure can be opened to retrieve contents.

NASA PPO has approved the use of VHP as a low-temperature sterilization modality, for simple surfaces, with specifications for time, rate, and H2O2 concentration levels. Complex geometries (e.g., vented boxes and electronic chassis inside the warm electronics box of a rover), however, require further directions. Thus, an additional study aims to describe the effect of VHP on electronic materials, materials with different configurations, solder joints, etc. Work has also begun for developing a portable VHP system that can be used locally (e.g., at the site of hardware integration in a cleanroom or on the launch pad).

Collecting Samples from Mars and the Consequences

For the first time, the Mars 2020 rover, carries a drill that can collect core samples of the most promising rocks and soils. The rover will set them aside in a “cache” on the surface of Mars. A future mission could potentially return these samples to Earth. That would help scientists study the samples in laboratories with special room-sized equipment that would be too large to take to Mars.

The question of “is there life on another planet?’ is an ancient thought. However, the consideration of protecting that life – is a relatively new one.  If life does exist on other planets, such as Mars, then we need to consider the consequences of what might occur when material is accidentally or inadvertently transferred between plants. Addressing these consequences is at the forefront of NASA’s Planetary Protection Policy.

NASA’s Planetary Protection Policy and Contamination

NASA, Jet Propulsion Laboratory, California Institute of Technology states,

“Planetary Protection addresses microbial contamination of the solar system by spacecraft that we launch from Earth (forward contamination). This contamination must be prevented in order to preserve the integrity of exploring the solar system; celestial bodies that may have once held an environment suitable for life (e.g., Mars and outer planet icy bodies) are especially vulnerable. Likewise, extraterrestrial contamination of the Earth and Moon (backward contamination), by way of sample return missions, must be prevented. We must approach with caution and preparedness in bringing unknown and potentially dangerous biological materials back to Earth.

While searching for life on the surface of a solar system body (via life-detection instruments) or in future samples returned to Earth, contamination could result in the “false-positive” indication of life. Thus, Planetary Protection’s primary strategy to prevent contamination is to confirm that spacecraft launched from Earth is clean. This precaution ensures that planets, and any life that might be there, remain in their original pristine state for scientific analysis. After the hardware is treated with various forms of microbial reduction, technicians assembling the spacecraft frequently wipe hardware surfaces with an alcohol solution to keep the spacecraft clean. Planetary Protection engineers carefully sample the surfaces and perform microbiology tests to show that the spacecraft meets the specified requirements for biological cleanliness.

In addition to this mission implementation role, the Biotechnology and Planetary Protection Group seeks to develop or adapt modern molecular analytical methods to rapidly detect, classify, and/or enumerate the widest possible spectrum of Earth microbes carried by spacecraft (on surfaces and/or in bulk materials, especially at low densities) before, during, and after assembly, test, and launch operations. Additionally, the group aims to identify new or improved methods, technologies, and procedures for spacecraft sterilization that are compatible with spacecraft materials and assemblies”

From the white paper The Evolution of Planetary Protection Implementation on Mars Landed Missions “ 

….”Cleaning and sterilization are distinctly different operations. Sterilization is the process to kill live microbes, while cleaning is a process that physically removes live and dead microbes and debris from hardware surfaces. The most commonly used current spacecraft hardware cleaning methods are precision cleaning and alcohol wiping. While these methods are efficient for cleaning massive contamination, they are not effective for removing micron and submicron-sized microbes and debris from hardware surfaces.

NASA planetary protection regulations state that a surface may be considered “sterile” if a microbial burden of less than 300 aerobic bacterial spores per meter2 can be treated to achieve a 104-fold reduction in viable endospores (spores).”  To read the entire paper link here

Count Down to NASA’ Mars 2020 Launch
The launch window for NASA’s Mars 2020 Rover named Perseverance is between July 17 – August 5, 2020. This time frame is the best landing opportunity as Earth and Mars are in good positions relative to each other. Consequently, it will take less power to travel to Mars in comparison to other dates when Earth and Mars are in different positions in their orbits. Landing is estimated for February 18, 2021. The mission duration is approximately 687 Earth days which is at least one Mars year. Guided Wave is excited to have our HPVA equipment be a part of this historic event.

NASA is determined to get its life-hunting Mars rover off the ground this summer despite the coronavirus outbreak.

Saybolt Color Analyzer Specially Priced Offer

Get Free Fiber and Flow Cell with Saybolt Analyer – Limited Time Offer

Simply request a quote by May 31st to get these savings and buy before December 31, 2020.

Get a Saybolt Analyzer System with FREE Sample Interface and Fibers for a limited time, Guided Wave is offering a Saybolt Analyzer including a free flow cell and the fiber cabling. (Fibers and the flow cell supplied are based on a standard configuration. Other configurations are available on request.)

The complete “ready-to-go” analytical system includes:

  1. Saybolt Analyzer (ClearView db photometer platform)
  2. Fiber Optic Cables (to remote the analyzer electronics from the sample point)
  3. Sample Interface (choice of Axial or Multi-Purpose Flow Cell)
  4. Control Software (built-in and pre-calibrated)

Get Your Quote Now and Lock in the Promotional Price and Savings!

With these uncertain times, we understand it may be hard to commit to purchasing soon. However, get your quote now and lock in this special promotional price, even if you buy later. Your quote with lower prices will be honored through the end of 2020. Remember there is no obligation to buy.

The Saybolt color scale varies from near water white (30) to dark yellow (-16).

Saybolt Color Scale (ASTM D156)

Guided Wave flow cells can measure the full range. But, if you need optimal precision at the high saybolt range then choose the 50mm pathlength Axial Flow Cell. Remember high saybolt means no color, low saybolt means high color.

Additional Options Available

  • Custom fiber length
  • Additional color scales such as ASTM can be added
  • ATEX Certification Ex d B+H2 T6 Gb Tamb -20°C to +40°C
  • Power Supply Converter
  • AC to 24VDC Power Supply
  • Spare Lamp for ClearView db
  • Field Service Start-up
  • Gold Brazed In-situ Transmission Probe

Reliable Saybolt Color Measurement with Low Maintenance

When accurate, actionable color data is critical, the Guided Wave Saybolt Color Analyzer is the preferred choice. Its linearity and repeatability, as well as, its low maintenance make it a cost-effective, smart choice to help optimize production, improve yields, ensure consistent product quality and enhance profitability.

Don’t miss this money-saving opportunity and complete the form below to receive a Saybolt Promotional Quote. To see the datasheet with specifications email [email protected] guided-wave.com or call for a free application review +1 916-648-4944 

Fiber Length Calculator

Need help estimating the maximum recommended distance between your analyzer and insertion probe or flow cell? Let Guided Wave’s Process Grade Fiber Length Calculator do the math for you. Simply pick a wavelength.

How to Choose Pathlength: for APHA Color

Pt-co-Scale
APHA Color Scale

The APHA/Platinum-Cobalt color scale is described in ASTM D1209. The ASTM method is an off-line manual laboratory method. The original test design required an observer to compare the color of a product to a known standard, and then judge the “color”. This color scale ranges from 0 to 500. The lowest value of 0 is referred to as water white. A value of 500 is distinctly yellow. (Above illustrates the contrast from 0- 100 range.)

Two Different Pathlengths are Recommended for APHA Applications

If the user needs to measure the whole range, then we recommend a 30 mm pathlength for either an SST Insertion Probe or MultiPurpose Flow Cell. This allows for long enough pathlength to measure the lightly colored samples and but short enough to still collect light for the dark samples. Conversely if the customer is interested in measuring the lightly color samples with scores less than 300 units, we recommend the 50 mm pathlength. The longer pathlength allows better precision for distinguishing between lightly colored samples.

Still Need Help Selecting a Pathlength?

Guided Wave selects a pathlength for the sample interface that provides the best solution from a technical and economic standpoint. Finding the balance between the signal-to-noise of the measurement and cost to manufacture, as well as accessibility for cleaning/maintenance by the user is always Guided Wave’s priority.  For more information contact us.



New Intern Joins from US Department of Defense

Guided Wave is proud to announce that Keaton Wakefield has joined our team as a software development intern. Keaton is part of the United States Department of Defense Skills Bridge program which links service members nearing the end of their enlistment with internships in industry. Keaton is currently working with Dr. Ryan Lerud and Dr. Steve Elam on improving the functionality of the OmniView software used with the NIR-O Full Spectrum Near Infrared Analyzer. According to Dr. Elam, “Keaton is a quick learner and is helping to bring new ideas to our development process. In just a few short weeks he has already contributed code improvements that will be included in our next software release.”

Keaton is currently attending Community College at American River College in Sacramento California. He is working for a degree in Software Engineering. Upon completion of the degree, Keaton plans on getting a job with a process automation company.

Thanks for your service Keaton and welcome to Guided Wave!

Corporate Fellow Dr. Terry Todd Retires

Guided Wave recently announced the retirement of Corporate Fellow Dr. Terry Todd. Terry was celebrated with a farewell party at the end of 2019 where the entire staff thanked him for his over 27 years of dedication to the company. Susan Foulk, Guided Wave President, stated: “Terry’s vision, knowledge and leadership have been instrumental in our success and we sincerely thank him for all he has done and taught us throughout the years.”

With more than 40 years’ experience in infrared molecular spectroscopy and radiation physics, Terry specialized in optical and spectroscopic instrument design for industrial applications. At Guided Wave since 1992, he was responsible for developing new NIR and UV-VIS analyzer technology and applications. While at Guided Wave Terry was at the forefront of all new product development and introduction, from the introduction of the Hydrogen Peroxide Monitor in 1997 to the release of the NIR-O spectrometer in 2018.  During this time (1998) Terry also re-engineered the Single-Sided Transmission (SST) process insertion probe to improve the optical efficiency and further enhance its ruggedness and reliability. Elements of these improvements were awarded US Patent #6,043,895 (March 2000). This pursuit of continuous improvement demonstrates a fundamental aspect of Dr. Todd business practices. To this day, the SST remains one of the most copied, reliable, rugged, and efficient process insertion probes available and is still producing robust sales after more than 28 years in the marketplace. Author of several technical publications and conference presentations, Terry also taught NIR spectroscopy to Guided Wave customers and sales representatives.

Terry received a BS in Mathematics from Northern Illinois University in 1969. He followed that with an MS in Physics from Penn State University in 1972 with his thesis on the emission spectrum of CO2. In 1976 he was awarded his Ph.D. in physics also at Penn State. His emphasis was on molecular physics, infrared high-resolution spectroscopy and optics. His thesis was titled, “Spectrometer Design, Emission Spectrum of CO2 and Secondary Wavelength Standards”.

Between finishing his Ph.D. and joining Guided Wave in 1992 Dr. Todd held and completed the following positions and accomplishments:

  • 1976-1978   NBS-NRC Post Doc National Bureau of Standards, Gaithersburg, MD
    • 1st IR Spectrum of CS
    • Constructed Diode Laser Spectrometer
  • 1978-1980   Laser Analytics (Spectra Physics), Lexington, MA
    • Diode Laser Spectroscopy/Instrument Development
  • 1980-1991   Exxon R&E Co., Florham Park, NJ
    • Instrument Development
    • Laser Pyrometer
    • NIR Octane Monitoring
  • 1991-1992  Todd Enterprises, Inc., Budd Lake, NJ

Terry plans to spend his retirement enjoying more time with family and pursuing his many hobbies, one of which will be working on the restoration of his Opel sedans and coupes. He also plans to continue with liquids processing (winemaking, maple syrup, and apple cider). Please join us in congratulating Dr. Terry Todd on his illustrious career and newfound retirement!

Curtis Mau was promoted from Sr. Product Development Engineer to the role of Manager of Engineering / R&D and will fulfill many of Dr. Todd’s previous responsibilities.

Time to start packing up 2019?

Looks like Dr. Terry Todd has some experience…

We caught Terry helping with the end of the year shipments.

Terry Todd, Ph.D., is Corporate Fellow for Guided Wave Inc. With more than 40 years’ experience in infrared molecular spectroscopy and radiation physics, he specializes in optical and spectroscopic instrument design for industrial applications. At Guided Wave for the last 27 years, he is responsible for developing new NIR and UV-VIS analyzer technology and applications.

What he does off-duty remains a mystery, but this time of year there is always a bit of speculation.

Wishing you a holiday season packed full of joy!

Thank you for your business, loyalty, and support this past year. May you and your family be of good cheer!
Sincerely,
All of us at Guided Wave (and Santa too)

Holiday Hours

Please note our offices will be closed on December 25th for Christmas and January 1st, 2020 for the New Year!

Guided Wave Releases Petrochemical Market Outlook in Fall 2019 Customer Newsletter

Cover of the Guide Post Newsletter Fall 2019

Guided Wave’s fall issue of its customer newsletter, “The Guide Post” was recently released. This issue focuses on current trends in the petrochemical, chemical and polymer marketplace.

Guided Wave can assist users in measuring various polyurethane compounds such as: Di-isocyanates, polyols, % water, and certain toxic by-products. Some relevant examples for these components include: %NCO, MDI, TDI, DEG, MEG, ETO, and phosgene. This issue covers the ability and power of online process monitoring, along with Guided Wave’s NIR analyzer systems, to well-equip the marketplace in various applications to meet the challenges of these petrochemical, chemical and polymer market trends.

In this Issue of The Guide Post Newsletter:

  • Market Trends – Petrochemical,Chemical and Polymer Outlook
  • Application Focus: Fast Reliable Measurements of Polyurethanes
  • Feasibility Study – Monitoring of Styrene, Acrylonitrile and MEK for Online Control on a Styrene Tower 
  • Sample Interface – Custom, Compatible, Certified Probes and Flow Cells
  • People – New Technical Staff Added to European Office
  • Education – How to Select Fiber Optic Cable for Spectroscopy
  • Product Update – M412 Retrofit to NIR-O – Saves You Money

Join Our Newsletter Mail List

To receive future copies of The Guide Post join Guided Wave’s mail list. The latest editions will be sent to you via email.

See Back Newsletter Issues

Guide Post Guided Wave Summer 2019 Issue

Guided Wave’s summer issue of its customer newsletter, “The Guide Post”  focuses on current trends in the oil and gas marketplace.

The spring issue of Guided Wave’s customer newsletter, “The Guide Post”  focuses on technology and discusses ways that Guided Wave has been able to continually solve challenging problems and help customers maintain their competitive edge.

Guide Post Spring 2019 Newsletter

Canadian Registration Number (CRN) Certified Probes for Process Spectroscopy

A Canadian Registration Number (CRN) is a number issued to the design of a pressure vessel or fitting by each province or territory of Canada. The CRN identifies the design has been accepted and registered for safe installation and use. As of October 2019, Guided Wave has submitted more than 3,500 different design configurations for our probes and flow cells to be CRN certified.

CRN certified probes and flow cells are engineered by Guided Wave to meet the strict safety and application requirements for the Canadian petrochemical, refining, and polymer markets. By coupling these probes with certified (CSA, ATEX, IECEX) process analyzers, Guided Wave can offer complete process monitoring solutions to Canadian customers. We currently have CRN registered designs for Ontario, Alberta, and Quebec. However, complete process monitoring solutions for all provinces can be implemented – contact us for more information.

All CRN probe sales include hydrotest and x-ray test results.

Gold Braze Single-Sided Transmission Probe and Gear Driven Extractor

NIR-Infrared spectroscopy with both DG-NIR and FT-NIR is now possible with the family of CRN certified in situ transmission probe and extractor.

Drawing Single-Sided Transmission (SST) Process Probe
Figure 1. Anatomy of an SST Process Probe

CRN Probe Features

  • Corrosion resistant construction
  • Rugged and vibration resistant design
  • Sealed against ambient moisture infiltration
  • High optical throughput for low noise spectroscopy
  • Temperatures to 300 °C
  • Pressures to 2000 psi or 138 bar
  • Higher pressures are available on request

Optional CRN Certified Accessories

The Single-Sided Transmission probe is available with an Extractor Assembly under a single CRN. This extractor accessory allows for a CRN probe to be easily adapted to different kinds of process installations. Additionally, the Extractor Assembly allows for quick and easy removal and servicing of probes, and avoids costly shutdowns by allowing the process to continue while the probe is offline. The standard flange on the extractor enables it to be installed into common process pipe configurations.

Certified Probes for High Pressure and Temperature Applications

The family of Heavy Duty probes are a special class of SST probes designed to withstand up to 2400 psi. The Heavy Duty probes can be constructed in 304, 304L, 316, 316L, and Hastelloy, with up to a 50 mm path length. 

CRN Certified Flow Cells for NIR Spectroscopy

Guided Wave’s family of 1, 2, 5, 10, and 20 mm pathlength flow cells are hydro-tested to demonstrate operation at 8100 pounds of pressure. This high safety factor has enabled Guided Wave to seek CRN certification for the flow cells in Ontario, Alberta, and Quebec.

Simple, Serviceable Flow Cell Design

Key elements of the CRN Certified flow cell (MPFC) design are simple, serviceable o-ring seals, the clean-out port, high optical efficiency, slip jointed conduit-ready connections, sapphire windows, a clean flow pattern, and o-ring sealed optics to prevent ambient moisture infiltration. The flow cell probe can be field disassembled for o-ring service and reassembled without changing the optical pathlength, a crucial parameter for repeatable measurements. The multi-purpose flow cell now boasts a dual seal at the sapphire “window-to-process” interface. This doubles protection for the expensive internal optical lenses.

Operating Range of CRN Flow Cell

The certified Multi-Purpose Flow Cell operates over the following pressure and temperature ranges:

  • Temperatures to 300 °C (o-ring material dependent)
  • Pressures to 1000 psi (o-ring durometer dependent)
  • Available in five standard pathlengths 1, 2, 5, 10, and 20 mm

CRN Certified Probes Compatible with Bruker and ABB Spectrometers

The CRN Certified probes and flow cells are manufactured by Guided Wave to facilitate full integration with any fiber-optic spectrometer manufacturer. The family of CRN certified devices are fully compatible with the Matrix-F FT-NIR analyzer, ABB’s full line of FT-NIR spectrometers, and AIT’s optical analyzers. The market-leading optical efficiency of our sample interfaces will improve the optical performance any spectrometer when connected with 400 to 600 micron fiber optical cables and SMA 905 or FC connectors.

Need Help Purchasing a CRN Certified Spectroscopy Probe or Flow cell?

Contact a Guided Wave sales representative to determine the best CRN Certified configuration for a process sample interface.